CONTENTS
· Invitation
· Faculty
· Scientific Agenda
· Continuing Medical Education
· Who Should Attend
· Objectives
· Registration
· General Information
· Hotel Accommodations
· Organizer

Dear Colleague,

It is with great pleasure that we invite you to join us for Perspectives in Melanoma XI. This fall’s conference, October 3-4, 2007 in Huntington Beach, California, promises to be an outstanding educational event.

Last year’s meeting in Noordwijk, The Netherlands welcomed over 700 attendees from 34 countries, and we expect this year’s meeting in the U.S. will build on this international success. With an interactive and exciting scientific agenda lined up, it will be a valuable educational experience for all melanoma-related disciplines.

Perspectives in Melanoma XI will provide an overview of recent advances and rigorous discussions of the most current and controversial topics in the fields of melanoma diagnosis and therapy. Led by authorities and current investigators in the field, the program will expand several of the most promising new leads from the bench to the clinic.

The conference will be held on the Wednesday and Thursday directly preceding SWOG’s annual meeting, so be sure to schedule a few extra days out of the office to attend both meetings.

We look forward to seeing you for what is certain to be a rewarding and dynamic experience; your diverse perspectives and contributions add immeasurable value to this international program!

Sincerely,
John M. Kirkwood, MD
Alexander M.M. Eggermont, MD, PhD
Vernon K. Sondak, MD

Boris C. Bastian, MD
UCSF Cancer Center
San Francisco, California

Dorothea Becker, PhD
University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania

Lisa H. Butterfield, PhD
University of Pittsburgh
Pittsburgh, Pennsylvania

Esteban Celis, MD, PhD
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida

Soheil S. Dadras, MD, PhD
Stanford School of Medicine
Stanford, California

Adil I. Daud, MD
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida

Alexander M.M. Eggermont, MD, PhD
Erasmus University Medical Center
Daniel Den Hoed Cancer Center
Rotterdam, The Netherlands

Christine S. Falk, PhD
University of Heidelberg
Heidelberg, Germany

Keith T. Flaherty, MD
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania

Thomas Gajewski, MD, PhD
University of Chicago
Chicago, Illinois

Jeffrey E. Gershenwald, MD
MD Anderson Cancer Center
Houston, Texas

Helen Gogas, MD
University of Athens
Athens, Greece

Valerie Guild
Charlie Guild Melanoma Foundation
Richmond, California

John M. Kirkwood, MD
University of Pittsburgh Medical Center
University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania

Kim A. Margolin, MD
City of Hope Comprehensive Cancer Center
Duarte, California

Julia Newton-Bishop, MD
Cancer Research UK
St. James’s University Hospital
Leeds, United Kingdom

Steven J. O’Day, MD
The Angeles Clinic and Research Institute
Los Angeles, California

Aleksandar Sekulic, MD, PhD
Mayo Clinic
Scottsdale, Arizona

Craig L. Slingluff, Jr., MD
University of Virginia
Charlottesville, Virginia

Peter T.C. So, PhD
Massachusetts Institute of Technology
Cambridge, Massachusetts

Vernon K. Sondak, MD
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida

Charles D. Surh, PhD
The Scripps Research Institute
La Jolla, California

John F. Thompson, MD
University of Sydney
Sydney, Australia

Richard Wahl, MD
Johns Hopkins University
Baltimore, Maryland

Hua Yu, PhD
City of Hope Comprehensive Cancer Center
Duarte, California

Wednesday, October 3, 2007

8:00 am
Welcome and introduction

Session I: Etiologic pathogenesis of melanoma
Moderator: Boris C. Bastian, MD

8:10 am
Opening address: Molecular analysis of melanoma progression
Dorothea Becker, PhD

8:40 am
Roles for vitamin D in melanoma pathogenesis
Julia Newton-Bishop, MD

9:00 am
Discussion

9:20 am
Break

Session II: Current and emerging diagnostic and imaging technologies
Moderator: John M. Kirkwood, MD

9:40 am
Ultrasonographic lymph node assessment
John F. Thompson, MD

10:00 am
Advances in optical imaging of the skin
Peter T.C. So, PhD

10:20 am
Keynote Lecture: The clinical utility of molecular genetics for melanoma diagnosis, classification, and therapy stratification
Boris C. Bastian, MD

11.00 am
Discussion

Session III: Advances in surgery and staging
Moderator: John F. Thompson, MD

1:20 pm
Serum and tumor profiling of human melanoma
Aleksandar Sekulic, MD, PhD

1:40 pm
The role of tumor lymphangiogenesis in melanoma nodal metastasis
Soheil S. Dadras, MD, PhD

2:00 pm
Advances in PET: Beyond FDG
Richard Wahl, MD

2:20 pm
The evolving role of surgery for melanoma: Metastasectomy and beyond
Jeffrey E. Gershenwald, MD

2:40 pm
Discussion

3:00 pm
Break

Session IV: Adjuvant therapy
Moderator: Helen Gogas, MD

3:20 pm
Molecular HLA typing and outcome
Helen Gogas, MD

3:40 pm
Autoimmunity and other markers of risk and response to interferon in ECOG studies
John M. Kirkwood, MD

4:00 pm
Predicting outcome in EORTC PEG-Intron studies
Alexander M.M. Eggermont, MD, PhD

4:20 pm
Should micrometastatic disease in the sentinel node receive adjuvant therapy?
Expert Panel: Alexander M.M. Eggermont, MD, PhD; Helen Gogas, MD; John M. Kirkwood, MD; and Vernon K. Sondak, MD

4:40 pm
Discussion

5:00 pm
Adjourn

Thursday, October 4, 2007

Session V: Metastatic disease: Contemporary and investigational targeted agents
Moderator: Alexander M.M. Eggermont, MD, PhD

8:00 am
What have we learned after 30 years of cooperative group trials?
Vernon K. Sondak, MD

8:20 am
Targeting the MAP kinase pathway: RAF and MEK inhibition
Keith T. Flaherty, MD

8:40 am
Targeting the PI3 kinase/AKT pathway: mTOR inhibition
Kim A. Margolin, MD

9:00 am
HDAC inhibitors: Overcoming resistance
Adil I. Daud, MD

9:20 am
New classes of therapeutics for melanoma
Steven J. O’Day, MD

9:40 am
Discussion

10:00 am
Break

Session VI: Regulation of immunity: Keys to melanoma therapy
Moderator: Thomas Gajewski, MD, PhD

10:20 am
The dichotomous influence of the immune system in melanoma
Thomas Gajewski, MD, PhD

10:40 am
Selective stimulation of T-cell subsets with antibody-cytokine complexes
Charles D. Surh, PhD

11:00 am
Overcoming STAT3 mediated negative immunoregulation
Hua Yu, PhD

11:20 am
Discussion

11:40 am
Special address to the melanoma community
Valerie Guild

Session VII: Melanoma vaccines
Moderator: Vernon K. Sondak, MD

2:00 pm
Experimental role of MHC and KIR: The role of NK and NK-Tcells in immune response and effector function
Christine S. Falk, PhD

2:20 pm
New insights and questions about the use of adjuvant and cytokines for optimizing immune responses to multipeptide melanoma vaccines
Craig L. Slingluff, Jr., MD

3:00 pm
Advances in vaccination
Esteban Celis, MD, PhD

3:20 pm
Therapeutic potential of genetically engineered vaccines
Lisa H. Butterfield, PhD

3:40 pm
Discussion

4:00 pm
Concluding remarks

4:15 pm
Adjourn

Imedex^®, LLC is accredited by the Accreditation Council
for Continuing Medical Education to provide continuing medical education for physicians.

Imedex, LLC designates this educational activity for a maximum of 12.25 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This educational activity is specifically designed for medical and surgical oncologists, dermatologists, researchers and other physicians, physicians-in-training and healthcare professionals (nurses, pharmacists) interested in and/or involved in the care of patients with melanoma and its consequences. No specialized knowledge or skill other than general familiarity with internal medicine, oncology or dermatology is required for successful participation in this activity.

After successful completion of this course, attendees should be able to:

• Discuss important aspects of the pathogenesis of melanoma
• Identify pathways involved in melanoma progression and their implications for potential therapy
• Integrate important advances in diagnostic and imaging technologies into clinical practice
• Describe emerging concepts and progress in the role of surgery and staging of melanoma
• Analyze recent progress in melanoma vaccine development
• Describe the role of the immune system in melanoma pathogenesis and identify immunological targets for therapy
• Identify currently available and investigational targeted agents for the management of metastatic melanoma
• Incorporate findings from recent clinical trials examining the role of adjuvant therapy into daily management of patients with melanoma

Click here to register for this program

REGISTRATION FEES
Regular . . . . . . . . . . . . . . . . . . . . . . . . $399
If payment received by September 27, 2007

Full/Onsite: . . . . . . . . . . . . . . . . . . . . . .$499
Registering after September 27, 2007

Group discount . . . . . . . . . . . . . . . . . . . –$50
Physicians only, cannot be combined with any other discounts

SWOG Members Discount . . . . . . . . . . .–$100
Physicians only, proof of eligibility must accompany registration

Nurses/Students/Residents . . . . . . . . . . .$199
Proof of eligibility must accompany registration

To Register: You may register online by September 27, 2007, or by calling Imedex at +1 (678) 242 0906. Registration confirmations will be issued before the meeting.

To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specified.

Group Discounts: Multiple registrants from the same institute or practice each receive a $50 discount off the published registration fees, provided all registration forms and payments are received together. Only one discount will apply per physician. Group discount cannot be combined with the SWOG discounts or the Nurses/Students/Residents fee.

SWOG members receive an additional $100 off the published registration fees. SWOG discount cannot be combined with Group discount or the Nurses/Students/Residents fee.

Payment: To pre-register, registration and payment must be received no later than September 27, 2007. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure the program is being held as scheduled and to confirm that the meeting is not full. Registration fees must be remitted by credit card, check, or wire transfer. Checks should be payable to Imedex. To pay via wire transfer, you must add $25 to each wire transaction to cover bank charges. Include the full name of the attendee and the name of the conference: Perspectives in Melanoma XI 283.

An attendee is not registered until full payment is received.

Wire to: Bank of America, ABA: 0260.0959.3, Account Info: Imedex, Inc., Account: 0000.0106.3308. If the wire originates outside the United States, please add this additional information: Clearing Bank: Bank of America, New York, Swift Code: BOFAUS3N, Clearing Account: 6550305831.

Registration Fee Inclusions: Registration fees include admittance to all scientific sessions, conference materials, processing of certificates of attendance or continuing medical education, and all event functions as specified in the program.

The Registration and Information Desk will be staffed:
Wednesday, October 3, 2007 7:00 AM – 5:30 PM
Thursday, October 4, 2007 7:30 AM – 4:30 PM

Hilton Waterfront Beach Hotel
21100 Pacific Coast Highway
Huntington Beach, California
Tel.: +1 (714) 845 8000 Ext. 2222
Fax: +1 (714) 845 8425

Book reservations here

The 100% non-smoking Hilton Waterfront Beach Hotel is situated in the beautiful seaside community of Huntington Beach, California, overlooking the Pacific Ocean and miles of white sand beaches. The hotel is close to several major California airports, including Los Angeles, Long Beach, and Orange County (John Wayne). Centrally located in the heart of Southern California, there are many major attractions nearby, including Disneyland, Disney’s Grand California Adventure, Knott’s Berry Farm, The Aquarium of the Pacific, and neighboring Laguna and Newport Beach.

Hilton Waterfront Beach Hotel rooms are designed with guest comfort and enjoyment in mind. Each hotel room offers a variety of amenities to ensure guest satisfaction. All of the 290 Hilton hotel rooms include private, furnished balconies, most with breathtaking views of the pristine Southern California coastline.

For the convenience of attendees, a limited number of rooms have been reserved until September 10, 2007 at a discounted rate of $199 single/double occupancy, plus tax, currently at 11%. This rate is not guaranteed outside the conference dates or after September 10, 2007.

To reserve your room please contact the Hilton Waterfront Beach Hotel in-house reservations department at +1 (714) 845 8000 Ext. 2222, email the reservations department at reservations@waterfrontresort.com or click here. To receive the group rate, callers must identify themselves as being with the “Perspectives in Melanoma XI” group or refer to it in the email. Internet users must enter the Group/Convention Code: IME. Reservation requests received after September 10, 2007 may not be guaranteed the group rate.

Guests wishing to cancel their hotel reservation will be allowed to do so without penalty if the cancellation request is received by the hotel no later than five days before guests scheduled arrival date. If the reservation is canceled less than five days prior to arrival or in the event of a no show the hotel may charge a one-night penalty to the guest.

Cancellation: For registration fees to be refunded, written notice of cancellation must be received at Imedex no later than September 27, 2007. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after September 27, 2007.

Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this program should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event program content is subject to change without notice.

          4325 Alexander Drive
          Alpharetta, GA 30022-3740 USA
          Tel.: +1 (770) 751 7332
          Fax: +1 (770) 751 7334
          Email: meetings@imedex.com
          Web: www.imedex.com