CONTENTS
· Invitation
· Faculty
· Scientific Agenda
· CME
· Who Should Attend?
· Objectives
· Registration
· General Information
· Hotel  Accommodations
· Organizer

Chair:
Richard M. Goldberg, MD
The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina

Co-Chair:
Mace L. Rothenberg, MD
Vanderbilt University
Nashville, Tennessee

It is with great pleasure and enthusiasm that we invite you to attend the 8th Annual Perspectives in Colorectal Cancer. We are excited to be meeting this year in sunny Miami, Florida, and are looking forward to an exceptional educational event.

The Annual Perspectives in Colorectal Cancer conference is designed to provide medical and radiation oncologists, gastroenterologists, colorectal surgeons, and oncology and gastroenterology nurses with a comprehensive overview of this important and evolving fi eld. Our panel of world-renowned experts will touch on the most salient aspects of the biology and pathogenesis, diagnosis, prevention, and treatment of colorectal cancer. We will discuss the status of the latest treatment modalities as well as promising emerging approaches to therapy. Our ultimate goal is to provide you with the information needed to optimize care of your colorectal cancer patients and to direct your attention to those trends and evolutions that are worth watching.

You will notice that we have added the name of the World Congress on Gastrointestinal Cancer to our conference to refl ect our joint association. The WCGC is the largest and most important international Congress on gastrointestinal cancers. The most recent advances in colorectal cancer as presented at the World Congress on Gastrointestinal Cancer in Barcelona will be summarized in a special overview lecture at Perspectives in Colorectal Cancer, providing attendees with worldwide perspectives and the most cutting edge information.

Also new this year, we will be reviewing and discussing challenging cases submitted by clinical oncology fellows. Special lectures on the historical perspective of where we’ve been and where we’re going in colorectal cancer, as well as pharmacoeconomics of colorectal cancer management will provide valuable take-home messages.

We are sure you will find this meeting to be informative and enjoyable. We look forward to welcoming you in Miami this September!

Sincerely,

Chair
Richard M. Goldberg, MD

Co-Chair
Mace Rothenberg, MD

David A. Ahlquist, MD
Mayo Clinic
Rochester, Minnesota

Timothy J. Akhurst, MD
Memorial Sloan-Kettering
Cancer Center
New York, New York

Bach Ardalan, MD
University of Miami
School of Medicine
Miami, Florida

John A. Baron, MD
Dartmouth Medical School
Lebanon New Hampshire

Nancy N. Baxter MD, PhD, FRCSC
University of Toronto
St. Michael’s Hospital
Toronto, Ontario, Canada

Al B. Benson, III, MD, FACP
Northwestern University
Chicago, Illinois

Margaret F. Bishop, ARNP, MSN
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire

Jeannine M. Brant, APRN-CNS, AOCN
St. Vincent Healthcare
Billings, Montana

Benjamin F. Calvo, MD
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina

Michael A. Choti, MD, FRCS
Johns Hopkins University Hospital
Baltimore, Maryland

Joseph T. Ferrucci, MD
Boston University
Boston, Massachusetts

Stephen Gallinger, MD, FRCSC
University of Toronto
Mount Sinai Hospital
Toronto, Ontario, Canada

Francis M. Giardiello, MD
Johns Hopkins University
Baltimore, Maryland

Richard M. Goldberg, MD
University of North Carolina
Chapel Hill, North Carolina

Axel Grothey, MD
Mayo Clinic
Rochester, Minnesota

Edward A. Levine, MD, FACS
Wake Forest University
Winston-Salem, North Carolina

Noralane M. Lindor, MD
Mayo Clinic
Rochester, Minnesota

Harvey J. Mamon, MD, PhD
Harvard Medical School
Brigham and Women’s Hospital
Boston, Massachusetts

Neal J. Meropol, MD
Fox Chase Cancer Center
Philadelphia, Pennsylvania

Reid M. Ness, MD
Vanderbilt, University
Nashville, Tennessee

Michael J. O’Connell, MD
Allegheny Cancer Center
Pittsburgh, Pennsylvania

Karen A. Roesser, RN, MS, AOCN
Thomas Johns Cancer Center
Richmond, Virginia

Mace L. Rothenberg, MD
Vanderbilt University
Nashville, Tennessee

David P. Ryan, MD
Harvard Medical School
Massachusetts General Hospital
Boston, Massachusetts

Pamela Hallquist Viale, RN, MS,
CS, ANP, AOCNP
University of California San Francisco
San Francisco, California

Christopher G. Willett, MD
Duke University
Durham, North Carolina

Friday, September 7, 2007

8:00 am
Welcome and introduction
Richard M. Goldberg, MD

Session I: Biology and pathogenesis
Moderator: Francis M. Giardiello, MD

8:10 am
Growth factor and signaling pathways in colorectal cancer
Francis M. Giardiello, MD

8:30 am
DNA mismatch repair gene defect and colorectal cancer risk
Stephen Gallinger, MD, FRCSC
           
8:50 am
Genetic predisposition and inherited colon cancer
Noralane M. Lindor, MD
           
9:10 am
Panel discussion

Session II: Screening and prevention
Moderator: David A. Ahlquist, MD

9:30 am
Optimal strategies for surveillance after initial treatment
Rein M. Ness, MD

9:50 am
Chemoprevention of colorectal cancer
John A. Baron, MD

10:10 am
Break

10:30 am
Virtual versus conventional colonoscopy
Joseph T. Ferrucci, MD

10:50 am
Molecular approaches to the early detection of colorectal cancer   
David A. Ahlquist, MD
           
11:10 am
Fellows clinical case studies: Determining screening recommendations based on family history

11:25 am
Panel discussion

11:45 am
Lunch break

Session IIIa: Colorectal surgery and staging
Moderator: Edward A. Levine, MD, FACS

1:15 pm
PET scan vs. whole-body CT scan in the preoperative staging of colorectal cancer
Timothy J. Akhurst, MD

1:35 pm
Advances in colorectal surgery
Nancy N. Baxter, MD, PhD, FRCSC             

1:55 pm
Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for the management of peritoneal surface dissemination from colonic origin
Edward A. Levine, MD, FACS

2:15 pm
Altering outcomes: Interventions for hepatic metastases
Michael A. Choti, MD, FRCS
           
2:35 pm
Panel discussion

2:55 pm
Break

Session IIIb: Supportive care
Moderator: Karen A. Roesser, RN, MS, AOCN

1:15 pm
Genetic testing and hereditary colorectal cancer: Implications for nurses
Karen A. Roesser, RN, MS, AOCN
                       
1:35 pm
Managing toxicities of targeted therapies for colorectal cancer
Pamela Hallquist Viale RN, MS, CS, ANP, AOCNP

1:55 pm
Effectively managing pain
Jeannine M. Brant, APRN-CNS, AOCN

2:15 pm
Concepts in caring for the patient with end stage colorectal cancer
Margaret F. Bishop, ARNP, MSN

2:35 pm
Panel discussion

2:55 pm
Break

Session IV: Adjuvant treatment for rectal cancer
Moderator: Al B. Benson, MD, FACP

3:15 pm
Key topics in the surgical management of rectal cancer
Benjamin F. Calvo, MD

3:35 pm
Perioperative adjuvant chemotherapy for locally advanced rectal cancer
Al B. Benson III, MD, FACP

3:55 pm
Adjuvant radiation therapy for rectal cancers: Evidence from randomized trials and applications to practice
Harvey J. Mamon, MD, PhD
           
4:15 pm
Panel discussion

4:35 pm
Closing remarks
Richard M. Goldberg, MD and Mace L. Rothenberg, MD

4:40 pm
Adjourn

Saturday September 8, 2007

8:00 am
Welcome
Mace L. Rothenberg, MD

Session V: Adjuvant treatment for locally advanced colon cancer
Moderator: Mace L. Rothenberg, MD

8:10 am
Currently available adjuvant treatment of stage II/III colon cancer
Bach Ardalan, MD

8:35 am
Developing evidence driven guidelines and applying them to clinical practice
Al B. Benson III, MD, FACP

9:00 am           
Targeted agents as radiation sensitizers for rectal cancer
Christopher G. Willett, MD

9:25 am
Panel discussion

9:5 am
Fellows clinical case studies: Adjuvant therapy for locally advanced colon cancer

10:10 am
Break

Session VI: Metastatic colorectal cancer I
Moderator: Richard M. Goldberg, MD

10:30 am
Frontline chemotherapy for metastatic colorectal cancer
Richard M. Goldberg, MD

10:55 am
Systematic continuum of care: Second and third-line treatment for metastatic colorectal cancer
Axel Grothey, MD
           
11:20 am 
The most recent advances in colorectal cancer: An update from the 8th World Congress on Gastrointestinal Cancer
Richard M. Goldberg, MD

11:45 am
Panel discussion

12:05 pm
Lunch break

Session VII: Metastatic colorectal cancer II
Moderator: Michael J. O'Connell, MD

1:35 pm
Angiogenesis inhibitors with efficacy in colorectal cancer
Axel Grothey, MD

2:00 pm
Integrating EGFR inhibitors into clinical practice
David P. Ryan, MD

2:25 pm           
Emerging therapies for metastatic colorectal cancer
Mace L. Rothenberg, MD

2:50 pm
Fellows clinical case studies: Metastatic colorectal cancer                                   

3:10 pm
Coffee break

3:30 pm
Perspectives on key advances in colorectal cancer: Where we’ve been and where we’re going
Michael J. O'Connell, MD

3:55 pm
Pharmacoeconomics of colorectal cancer management
Neal J. Meropol, MD

4:20 pm
Panel discussion

4:30 pm
Closing remarks
Richard M. Goldberg, MD and Mace L. Rothenberg, MD

4:35 pm
Adjourn

Physicians:
Imedex Accreditation Services, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Imedex Accreditation Services, LLC designates this educational activity for a maximum 13.00 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Nurses:
This program (0907) has been approved by an AACN Certification Corporation-approved provider (Provider # 00013328) under established AACN Certification Corporation guidelines for a maximum of 12.50 contact hours, CERP Category A.

This conference is specifically designed for medical and radiation oncologists, gastroenterologists
and colorectal surgeons, and other healthcare professionals (gastroenterology and oncology nurses) in active clinical practice who wish to review and update their knowledge and management of colorectal cancer. No specialized knowledge is needed for participation beyond basic familiarity with gastroenterology.

After successfully completing this continuing medical education program, participants will be able to:

• Comment on the latest developments in our understanding of colorectal tumor biology
• Identify challenges related to screening and surveillance of colorectal cancer patients
• Discuss state-of-the-art surgical and staging procedures for colon and rectal cancer
• Select the most appropriate adjuvant regimens for patients with colon and rectal cancer
• Describe a systematic continuum of care for patients with advanced disease including selecting the most appropriate first and second line chemotherapy regimens
• Discuss supportive care issues in the management of colorectal cancer patients
• Identify promising new agents in the treatment of colorectal cancer

REGISTRATION FEES
Full/On-Site Physician...............$395
If payment received after August 30, 2007

Group Discount (physicians only)*........... -$50
*cannot be combined with any other discounts

Nurses/Residents/Students* .....................$75
*Proof of eligibility must accompany registration

TRAVEL/EDUCATION GRANTS FOR FELLOWS AND RESIDENTS
Applications are now available for a limited number of travel/education grants for fellows or residents to The 8th Annual Perspectives in Colorectal Cancer. The grant will provide each follow or resident with complimentary conference registration, up to 2 nights (between September 6, 2007 and September 8, 2007) single or double occupancy at the InterContinental and round-trip air or train travel to Miami, Florida (up to $400). Applicants are required to submit at least one clinical case for possible presentation at the meeting in one or more of the following areas: 1) determining screening recommendations based on family history, 2) adjuvant therapy for locally advanced colon cancer, 3) metastatic colorectal cancer. Applications are available online at www.imedex.com/285application.pdf, or may be requested by email to meetings@imedex.com. Deadline to receive grant applications is July 10, 2007. Notification of acceptance will be sent by July 20, 2007.

Multiple registrants from the same institute or practice each receive a $50 discount off the published registration fees, provided all registration forms and payments are received together. Only one discount will apply per physician. Discounts are not available for Nurses/Residents/Students rate.

Register
You may register on-line or call Imedex at +1 (770) 751 7332. Registration confirmations will be issued before the meeting.

To qualify for special registration fees, registration and full payment must be received by Imedex by
the dates specified.

Payment
Registration fees can be remitted by credit card, check, or wire transfer. Checks should be payable
to Imedex. To pay via wire transfer, you must add $25 to the registration fee to cover bank charges.
Include the full name of the attendee and the name of the conference: 285 – Perspectives in
Colorectal Cancer. Attendee is not registered until full payment is received.

Wire to: Bank of America, ABA: 0260.0959.3, Account Info: Imedex, Inc., Account: 0000.0106.3308. If the wire originates outside the United States, please add this additional information: Clearing Bank: Bank of America, New York, Swift Code: BOFAUS3N, Clearing Account: 6550305831.

Registration Fee Inclusions
Registration fees include admittance to scientific sessions, conference materials and all functions as specified in the program.

Cancellation
For registration fees to be refunded, written notice of cancellation must be received at Imedex no later than August 30, 2006. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after August 30, 2007.

Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this program should be cancelled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event program content is subject to change without notice.

Conference Location and Registration Hours
InterContinental Miami
100 Chopin Plaza
Miami, Florida 33131
Tel.: +1 (305) 577 1000
Fax: +1 (305) 577 0384
www.icMiamiHotel.com

The Registration and Information Desk will be staffed:
Friday, September 7, 2007 . . . . 7:00 am - 5:30 pm
Saturday, September 8, 2007 . . . . 7:00 am - 5:30 pm

Discounted Airfares
Contact conference travel agent, Age of Travel, for assistance with your travel needs. Age of Travel can also accommodate pre- and post-conference extensions.
Tel.: (800) 523 4954 or +1 (404) 591 7120
Email: Imedex@ageoftravel.com

InterContinental Miami
100 Chopin Plaza
Miami, Florida 33131
Tel.: +1 (305) 577 1000
Fax: +1 (305) 577 0384
www.icMiamiHotel.com

Miami is truly one of the world’s most vibrant tropical playgrounds. The InterContinental Miami offers richly appointed accommodations and state of the art conference facilities. Discover this enchanting downtown Miami hotel in a magical setting and enjoy the following:

• Overlooking Biscayne Bay, in the heart of Miami
• Minutes from South Beach, the Port of Miami, Coconut Grove, and Coral Gables
• Only 7.5 miles from Miami International Airport (MIA)
• Just 25 miles from Fort Lauderdale International Airport (FLL)
• Modern fitness center
• Three stylish restaurants and cocktail lounges

For the convenience of attendees, a limited number of rooms have been reserved until August 14, 2007 at a discounted rate of $159 single/double occupancy, plus tax, currently at 13%. This rate is not guaranteed outside the conference dates or after August 14, 2007.

To reserve your room please contact the InterContinental Miami reservations department at +1 (305) 577 1000. To receive the group rate, callers must identify themselves as being with the 8th Annual Perspectives in Colorectal Cancer group. Reservation requests received after August 14, 2007 may not be guaranteed the group rate.

          4325 Alexander Drive
          Alpharetta, GA 30022-3740 USA
          Tel.: +1 (770) 751 7332
          Fax: +1 (770) 751 7334
          Email: meetings@imedex.com
          Web: www.imedex.com